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Clinical trials

Northwell Health is a leader in groundbreaking orthopedic treatments and novel services because of an extraordinary commitment to improving our patients’ quality of life. The Northwell Health Orthopaedic Institute is at the forefront of orthopedic research—from innovative new therapies for osteoarthritis to harnessing light waves to heal muscles after surgery—so patients can rest assured knowing that they are in the most capable hands. By participating in research and exclusive clinical trials, our physicians are able to provide patients with medical treatments of the future—today.

Our ultimate mission is to advance the science of medicine and to have a major impact on the delivery of orthopedic care for our patients. From attending physicians to research coordinators to visiting scholars, the Orthopaedic Institute draws on the vast expertise and resources of the Northwell Health system to improve the lives of our patients.

Our orthopedic clinical trials
We hope to prospectively analyze a population of patients with patellofemoral pain syndrome (PFPS) and determine the incidence of concomitant ipsilateral femoral acetabular impingement (FAI)...
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery...
The purpose of this study is to evaluate surgical insision complications in patients undergoing a total knee arthroplasty (TKA) when a negative pressure therapy dressing is used to treat the closed incision as compared to a standard dressing.
The purpose of this study is to prospectively determine, at 12 months post-surgical repair of full thickness rotator cuff tears, the safety and efficacy of treating full thickness rotator cuff repairs with pulsed electromagnetic fields (PEMF)...
Hyaluronic acid (HA) is a major component of synovial fluid. Intra-articular injections of hyaluronic acid represents a commonly used therapeutic option to relieve osteoarthritic (OA) symptoms, including pain and joint function...
Post-operative blood clots after orthopaedic procedures are a rare, but serious potential event.  Because of their effectiveness, it is now considered standard practice to take a blood thinner post-operatively to reduce the risks blood clots after hip or knee replacements...
The objective of this post-market, prospective clinical study is to assess posterolateral fusions using FIBERGRAFT® BG Matrix mixed with autograft bone and bone marrow aspirate in patients that have either (1) spinal stenosis and/or spondylolisthesis requiring a fusion; or (2) degenerative disc disease (DDD) with or without radiculopathy; and who are not responding to non-operative treatment...
The e-vive trial for reducing pain and improving function is now enrolling patients with knee arthritisWhat is e-vive? The CyMedica e-vive system is an app based muscle strengthening solution designed to helpyou be proactive with your osteoarthritis conveniently from home...
The purpose of this study is to assess the safety and efficacy of TA-ER in the treatment of rotator cuff disease. The study will enroll 65 patients in a longitudinal case series level IV study using extended release triamcinolone to treat shoulder pain from rotator cuff disease...
To assess whether the unipolar electrocautery is non-inferior to saline-coupled bipolar sealer with respect to estimated blood loss as calculated by Gross’ formula in patients undergoing primary unilateral total knee arthroplasty.


All of our patient care is grounded in medical research conducted by our orthopedists, whether through multi-institutional studies, industry- or government-sponsored trials, or in collaboration with researchers at the Feinstein Institutes for Medical Research, which has performed innovative investigations on tendon repair and cartilage regeneration—and which ranks in the top 6th percentile of all National Institutes of Health (NIH) grants awarded to research centers.

  • The foot and ankle program is actively pursuing research projects, including a retrospective study of ankle fractures for syndesmotic injury and a study focusing on inpatient versus outpatient settings for ankle fracture treatment.
  • The joint replacement team works closely with the researchers at the Feinstein Institutes to improve treatments for musculoskeletal injuries. 
  • Our orthopedic research scientists and practitioners are constantly shedding new light and offering new hope for patients with chronic back pain and other conditions that impact the spine.
  • The trauma and fracture team is actively involved in research through collaboration with the Feinstein Institutes. Current areas of focus include using 3D printing to correct bone defects and evaluation of hip fracture data and patient success rates.


Headshot of Christina Brennan

Christina Brennan, MD, MBA

Director of Clinical Research & Data Quality

Nicholas Sgaglione, MD

Senior Vice President and Executive Director

Chair, Orthopaedic Surgery, Long Island Jewish Medical Center and North Shore University Hospital, Chair, Orthopaedic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Daniel A. Grande, PhD

Associate Professor, Center for Bioelectronic Medicine, Feinstein Institutes for Medical Research

Director, Orthopaedic Research Laboratory, Feinstein Institutes for Medical Research, Associate Professor, Molecular Medicine and Orthopedic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

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