John Andrew Boockvar, MD

John Andrew Boockvar, MD

Vice Chair, Department of Neurosurgery
Lenox Hill Hospital

Director, Brain Tumor and Pituitary/ Neuroendocrine Center
Lenox Hill Hospital & Manhattan Eye, Ear and Throat Hospital

Investigator, Laboratory for Brain Tumor Biology
The Feinstein Institute for Medical Research

Professor, Neurosurgery and Otolaryngology/Head and Neck Surgery
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Dr. Boockvar is the Vice Chair of the Department of Neurosurgery at Lenox Hill Hospital and Director of the Brain Tumor Center, and the Pituitary/Neuroendocrine Center of the Department of Neurosurgery and the New York Head and Neck Institute at Lenox Hill and Manhattan Eye, Ear and Throat Hospitals. Dr. Boockvar is a Professor of Neurological Surgery and Otolaryngology/Head and Neck Surgery at the Zucker School of Medicine. Dr. Boockvar is an investigator at the Feinstein Institute for Medical Research where he directs the Laboratory for Brain Tumor Biology and Therapy.

Dr. Boockvar is internationally known for his surgical expertise and for providing patients with safe, effective, and minimally invasive treatment for brain tumors, skull base disorders, and disorders of the spine. Dr. Boockvar's surgical expertise is in benign and malignant brain tumors, skull base and endoscopic pituitary surgery, spinal and peripheral nerve tumors, minimally invasive spinal surgery, and complex spinal disorders. Dr. Boockvar has been recognized for his novel research in brain tumors and stem cell biology. Dr. Boockvar has been repeatedly named to the lists of New York Magazine’s Top Docs, Best Doctors in New York-Castle Connolly, New York SuperDoctors, America's Top Surgeons, America's Best Doctors, and America's Best Doctors for Cancer. His research has been widely published and he has received numerous national awards including the Eric Lichtenstein Humanitarian Award from Voices Against Brain Cancer for his compassionate work in treating patients with brain cancer. In 2016 Dr. Boockvar was elected to the prestigious Academy of Neurological Surgeons.  In 2017 he was elected to the Senior Society of the American Board of Neurological Surgery. 

Dr. Boockvar has been repeatedly featured on CNN, ABC, CNBC, CBS, and Fox News Channel, and has appeared on The Dr. Oz Show as well as in the New York Times, New York Daily News, and Crain's Business Journal among others. Dr. Boockvar was a featured neurosurgeon on the ABC hit show NY MED. In 2016, He was one of only two neurosurgeons in the nation to be featured in the documentary “Surviving Terminal Cancer”. Most recently, Dr. Boockvar was featured on a special episode of the Dr. Oz Show on brain tumorsGood Morning America and the Today Show with Megyn Kelly. Dr. Boockvar is also an honorary surgeon of the NYPD and the New York State Troopers.

Training and Experience

Dr. Boockvar received a B.A from the University of Pennsylvania. Like his father, grandfather, and great-grandfather before him, Dr. Boockvar received an M.D. from SUNY Brooklyn-Downstate Medical Center. Dr. Boockvar graduated summa cum laude with Distinction in Research and was medical school class valedictorian. Dr. Boockvar did his surgical internship and neurosurgical residency at the Hospital of the University of Pennsylvania. Dr. Boockvar did his NIH-supported post-doctoral research training in Neuro-oncology at the University of Pennsylvania Cancer Center. At Penn, Dr. Boockvar received the prestigious Ruth Kirstein NRSA award for his research into stem cell biology and malignant brain tumors. He also directed the University of Pennsylvania pituitary and skull base laboratory and completed a dedicated complex spine surgery fellowship. After leaving Penn, Dr. Boockvar completed an National Cancer Institute funded Mentored Career Development Award under Eric Holland, MD and Shahin Rafi, MD at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, respectively. Immediately prior to joining Northwell, Dr. Boockvar was Professor of Neurological Surgery at Weill Cornell Medical College/ New York Presbyterian Hospital. At Weill Cornell, Dr. Boockvar was Co-Director of Neurosurgical Oncology, Head of the Laboratory for Translational Stem Cell Research and Director of the Brain Tumor Research Group.

Research

Dr. Boockvar currently co-directs the Laboratory for Brain Tumor Biology and Therapy at the Feinstein Institute for Medical Research. His laboratory interests have focused on adult human neural stem cell biology as it relates to brain tumor formation and resistance to therapy. Dr. Boockvar is a world expert on blood brain barrier disruption to improve the delivery of therapeutics to the human brain. Dr. Boockvar is the principal investigator of several cutting edge clinical trials using blood brain barrier disruption to deliver high dose chemotherapy for patients with malignant brain tumors that have been featured in the New York Times and Wall Street Journal. Dr. Boockvar has served as Editor-in-Chief of the journal Current Stem Cell Research and Therapy and is an editorial board member of the Journal of Neuro-Oncology, Neurosurgery, Journal of Neurosurgery, and Recent Patents on Anti-Cancer Drug Discovery. Dr. Boockvar directs the Brain Tumor Biotech Center at the Institute that seeks to bridge the translational gap between basic and clinical science for patients with malignant brain tumors. Dr. Boockvar's laboratory has been funded by the National Institutes of Health and he was recently awarded the American Association of Neurological Surgeons Pinnacle Partners Award for his research into brain tumors. He has also won research awards from Voices Against Brain Cancer, the American Brain Tumor Association, the Starr Foundation, Anspach Companies, and the Adelson Foundation.

In the News

In 2007, Dr. Boockvar received acclaim for helping to save a window washer who had fallen 47 stories. By operating on both his brain and spinal cord, Dr. Boockvar not only saved the man's life but helped him to walk again and regain normal functioning (see The New York Times article about the surgery, as well as a 2014 update on the patient in the New York Post). Dr. Boockvar has been on the cover of The New York Times Science Times twice. On November 9, 2010, the anniversary issue of the Science Times asked science reporters and top researchers to provide their watch list for noteworthy advances in 2011 and to identify which "fields are hot." This list included Dr. Boockvar and the studies he is conducting for people with Glioblastoma Multiforme (see article).

Clinical Trials

Phase 1 Trial of Super-selective Intra-arterial Cerebral Infusion of Trastuzumab After Blood-Brain Barrier Disruption for the Treatment of Cerebral Metastases of HER2/neu Positive Breast Cancer 
PI: John Boockvar, MD

The purpose of this study is to evaluate the safety of administering a single dose of trastuzumab into your artery for the treatment of your brain metastasis(es) from HER2/neu positive breast cancer. This study will try to determine the best tolerated single dosage of trastuzumab administered into arteries by gradually increasing the dosage given to participants as the study progresses. Early participants will receive a dosage of 1 mg/kg. As more participants enroll into the study, this single dosage will be increased at designated levels up to 8 mg/kg, if it’s determined to be safe to increase. Trastuzumab is a type of antibody, which is a protein used by the body’s immune system to fight against pathogens such as bacteria and viruses. This antibody binds to cell receptors known as the HER2/neu tyrosine kinase receptor. These receptors are expressed in certain cancer subtypes such as breast cancer. By blocking signaling through this HER2/neu receptor, trastuzumab can slow down or stop the over-expression of the HER2/neu protein. Over-expression of HER2/neu has been shown to play a role in the development and progression of certain types of breast cancer. Therefore, by slowing down or stopping the expression of HER2/neu, we hope to slow down or stop the growth of your metastasis(es) and increase the responsiveness to therapy.  

Phase I Trial of Super-Selective Intra-Arterial Infusion of Cetuximab (ERBITUX) with or without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck 
PI: John Boockvar, MD

This is an open-label, non-randomized, two arm, Phase I research study of superselective intraarterial Cetuximab (Erbitux) with or without radiation therapy for treatment of recurrent unresectable squamous cell carcinoma of the head and neck (HNSCC). Cetuximab has recently emerged as a promising biological agent in the management of HNSCC. It is an epidermal growth factor receptor (EGFR) inhibitor which increases the radiosensitivity of tumors to radiotherapy (RT), and has been proven to be effective. A large body of evidence supports the theoretical attractiveness of intra-arterial chemotherapy, related to the first pass of the drug through the tumor bed and to the possibility of increasing the doses of the chemotherapeutic agent, thus minimizing systemic toxic side effects. Theoretically, a higher dose of Cetuximab saturating the tumor tissue’s EGFR receptor will increase its responsiveness with or without concurrent radiation therapy.

Phase I Trial of Super-Selective Intraarterial Carotid Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma
PI: John Boockvar, MD

Superselective Intraarterial Cerebral Infusion (SIACI) is a technique that can effectively increase the concentration of drug delivered to the brain while sparing the body of systemic side effects. One currently used drug called, Cetuximab (Erbitux) has been shown to be active in human brain tumors but its actual CNS penetration is unknown. This phase I clinical research trial will test the hypothesis that Cetuximab can be safely used by direct intracranial superselective intraarterial infusion up to a dose of 250mg/m2 to ultimately enhance survival of patients with relapsed/refractory GBM/AA. By achieving the aims of this study the investigators will determine the the toxicity profile and maximum tolerated dose (MTD) of SIACI Cetuximab. The investigators expect that this study will provide important information regarding the utility of SIACI Cetuximab therapy for malignant glioma, and may alter the way these drugs are delivered to the investigators patients in the near future.

Phase I Trial Of Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed Glioblastoma Multiforme And Anaplastic Astrocytoma
PI: John Boockvar, MD

This phase I clinical research trial will test the hypothesis that Temozolomide can be safely used by Superselective Intraarterial Cerebral Infusion (SIACI) up to a dose of 250mg/m2 to ultimately enhance survival of patients with newly diagnosed Glioblastoma Multiforme and Anaplastic Astrocytoma. Data suggests that Temozolomide is active in newly diagnosed GBM but that current response rates can be improved and toxicity with systemic delivery could be avoided with selective delivery techniques such as SIACI. Phase I Trial of Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma PI: John Boockvar, MD A recent study showed that IV Bevacizumab (Avastin) treatment was followed by clinically meaningful hearing improvement, tumor-volume reduction, or both in some, but not all, patients with vestibular schwannoma who were at risk for complete hearing loss or brainstem compression from growing VS. Because of these promising results in preliminary studies of IV Bevacizumab and because of our significant experience with the safety of intraarterial chemotherapy, this novel study will offer a safe treatment for patients with VS. This will be the only center in the United States where this trial is being offered.

Phase I/II Trial of Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma
PI: John Boockvar, MD

This phase I/II clinical research trial will test the hypothesis that repeated direct intracranial superselective intraarterial infusion Bevacizumab (15mg/kg) can be safely administered to enhance survival of patients with relapsed/refractory Glioblastoma Multiform and Anaplastic Astrocytoma. The current standard of care for recurring GBM is for patients to receive Bevacizumab (Avastin) intravenously (IV) at 10mg/kg every two weeks until their tumor grows more than 25%. By achieving the aims of this study we will determine if IV therapy with Bevacizumab should be combined with repeated selected intra-arterial Bevacizumab to improve progression free and overall survival.

Phase I/II Trial Of Repeated Super-Selective Intraarterial Cerebral Infusion Of Bevacizumab (Avastin) Plus Carboplatin (Paraplatin) For Treatment Of Relapsed/Refractory Glioblastoma Multiforme And Anaplastic Astrocytoma
PI: John Boockvar, MD

This phase I/II clinical research trial is an extension of our Phase I IA Avastin trial in that we seek to test the hypothesis that repeated dosing of intra-arterial Bevacizumab is safe and effective in the treatment of recurrent malignant glioma. Additionally we will analyze if a combination with IA Carboplatin will further improve the treatment response. By achieving the aims of this study we will also determine if IV therapy with Bevacizumab with IV Carboplatin should be combined with repeated selected intra-arterial Bevacizumab plus Carboplatin to improve progression free and overall survival.

Phase I/II Trial Of Repeated Super-Selective Intraarterial Intracranial Infusion Of Cetuximab (Erbitux) For Treatment Of Relapsed/Refractory Glioblastoma Multiforme And Anaplastic Astrocytoma PI: John Boockvar, MD

This phase I/II clinical research trial is an extension of that trial in that we seek to test the hypothesis that repeated dosing of intra-arterial Cetuximab is safe and effective in the treatment of recurrent malignant glioma. By achieving the aims of this study we will also determine if IV therapy with Cetuximab should be combined with repeated selected intra-arterial Cetuximab to improve progression free and overall survival. We expect that this project will provide important information regarding the utility of repeated SIACI Cetuximab therapy for malignant glioma, and may alter the way these drugs are delivered to our patients in the near future.

Phase I/II Trial of Repeated Superselective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed Glioblastoma Multiforme
PI: John Boockvar, MD

This phase I/II clinical research trial will test the hypothesis that repeated direct intracranial intraarterial infusion of Bevacizumab (15 mg/kg) can be safely administered to enhance survival of subjects with newly diagnosed Glioblastoma multiforme while they receive standard of care. We expect that this project will provide important information regarding the utility of repeated SIACI Bevacizumab therapy for newly diagnosed malignant glioma, and may alter the way these drugs are delivered to our patients in the future. Click here to view Dr. Boockvar's presentation on Super Selective Intra-arterial Infusion for brain tumors.

Publications

Colony Stimulating Factor-1 Receptor Inhibitors-A 4 for 1 Deal in the Desire to Improve Glioma Radiotherapy. Skeie B, Ruggieri R, Boockvar JA, Symons M. Neurosurgery. 2017 Sep 1

Management of Tiny Meningiomas: To Resect or Not Resect. Schneider JR, Kulason KO, White T, Pramanik B, Chakraborty S, Heier L, Ray AE, Anderson TA, Chong DJ, Boockvar J.Cureus. 2017 Jul 25

Do craniopharyngioma molecular signatures correlate with clinical characteristics? Omay SB, Chen YN, Almeida JP, Ruiz-Treviño AS, Boockvar JA, Stieg PE, Greenfield JP, Souweidane MM, Kacker A, Pisapia DJ, Anand VK, Schwartz TH J Neurosurg. 2017 Jul 14

Long-term benefit of intra-arterial bevacizumab for recurrent glioblastoma. Alter RA, White TG, Fanous AA, Chakraborty S, Filippi CG, Pisapia DJ, Tsiouris AJ, Boockvar JA J Exp Ther Oncol. 2017 May

Use of Chimeric Antigen Receptor T Cells as a Potential Therapeutic for Glioblastoma. Babar Khan M, Chakraborty S, Boockvar JA. Neurosurgery. 2017 May 1

Radiation Exposure and Safety Precautions Following 131Cs Brachytherapy in Patients with Brain Tumors. Yondorf MZ, Schwartz TH, Boockvar JA, Pannullo S, Stieg P, Sabbas A, Pavese A, Trichter S, Nedialkova L, Parashar B, Nori D, Chao KS, Wernicke AG. Health Phys. 2017 Apr

Frameless and Maskless Stereotactic Navigation with a Skull-Mounted Tracker:A Technical Report. Fanous AA, White TG, Hirsch MB, Chakraborty S, Costantino PD, Langer DJ, Boockvar JA. World Neurosurg. 2017 Mar 11

Effect of Whole Brain Radiation Therapy on Cognitive FunctionSchneider JR, Chakraborty S, Boockvar JA. Neurosurgery. 2017 Mar 1

Glioblastoma spheroids produce infiltrative gliomas in the rat brainstem. Zhou Z, Luther N, Singh R, Boockvar JA, Souweidane MM, Greenfield JP. Childs Nerv Syst. 2017 Feb 24

Curcumin changes the polarity of tumor-associated microglia and eliminates glioblastoma. Mukherjee S, Baidoo J, Fried A, Atwi D, Dolai S, Boockvar J, Symons M, Ruggieri R, Raja K, Banerjee P. Int J Cancer. 2016 Dec 15

Gross Total Resection of Glioblastoma Improves Overall Survival and Progression-Free Survival Compared to Subtotal Resection or Biopsy Alone. Khan MB, Chakraborty S, Boockvar JA. Neurosurgery. 2016 Dec

Intra-arterial cetuximab for the treatment of recurrent unresectable head and neck squamous cell carcinoma. Tham T, White TG, Chakraborty S, Lall RR, Ortiz R, Langer DJ, Shatzkes D, Filippi CG, Kraus D, Boockvar JA, Costantino PD. J Exp Ther Oncol. 2016 Nov

Durability of single dose intra-arterial bevacizumab after blood/brain barrier disruption for recurrent glioblastoma. Chakraborty S, Filippi CG, Burkhardt JK, Fralin S, Ray A, Wong T, Ortiz R, Langer DJ, Boockvar JA. J Exp Ther Oncol. 2016 Nov

Transdifferentiation-Induced Neural Stem Cells for the Treatment of Malignant Gliomas. Chakraborty S, Schneider J, Boockvar JA. Neurosurgery. 2016 Oct

Transdifferentiation Induced Neural Stem Cells for the Treatment of Malignant Gliomas. Chakraborty S, Schneider J, Boockvar JA. Neurosurgery. 2016 Aug

Erratum to: Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study. Chakraborty S, Filippi CG, Wong T, Ray A, Fralin S, Tsiouris AJ, Praminick B, Demopoulos A, McCrea HJ, Bodhinayake I, Ortiz R, Langer DJ, Boockvar JA. J Neurooncol. 2016 Jul

Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study. Chakraborty S, Filippi CG, Wong T, Ray A, Fralin S, Tsiouris AJ, Praminick B, Demopoulos A, McCrea HJ, Bodhinayake I, Ortiz R, Langer DJ, Boockvar JA. J Neurooncol. 2016 Jul

The FIRST Trial: Implications for Neurosurgery. Chakraborty S, Schulder M, Boockvar JA. Neurosurgery. 2016 Jun

Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy. Singh R, Kesavabhotla K, Kishore SA, Zhou Z, Tsiouris AJ, Filippi CG, Boockvar JA, Kovanlikaya I. AJNR Am J Neuroradiol. 2016 May 26

Neuro-oncology biotech industry progress report. Chakraborty S, Bodhinayake I, Chiluwal A, Langer DJ, Ruggieri R, Symons M, Boockvar JA. J Neurooncol. 2016 May

Anterior Cervical Discectomy and Fusion (ACDF): Comparison Between Zero Profile Implants and Anterior Cervical Plate and Spacer. Alimi M, Njoku I, Hofstetter CP, Tsiouris AJ, Kesavabhotla K, Boockvar J, Navarro-Ramirez R, Härtl R. Cureus. 2016 Apr 17;8(4)

Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy. Singh R, Kesavabhotla K, Kishore SA, Zhou Z, Tsiouris AJ, Filippi CG, Boockvar JA, Kovanlikaya I. AJNR Am J Neuroradiol. 2016 May 26. 

Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study. Chakraborty S, Filippi CG, Wong T, Ray A, Fralin S, Tsiouris AJ, Praminick B, Demopoulos A, McCrae H, Bodhinayake I, Ortiz R, Langer DJ, Boockvar JA.J Neurooncol. 2016 Mar 5. 

Neuro-oncology biotech industry progress report.Chakraborty S, Bodhinayake I, Chiluwal A, Langer DJ, Ruggieri R, Symons M, Boockvar JA.J Neurooncol. 2016 Feb 20. [Epub ahead of print]

The cost-effectiveness of surgical resection and cesium-131 intraoperative brachytherapy versus surgical resection and stereotactic radiosurgery in the treatment of metastatic brain tumors.Wernicke AG, Yondorf MZ, Parashar B, Nori D, Clifford Chao KS, Boockvar JA, Pannullo S, Stieg P, Schwartz TH.J Neurooncol. 2016 Jan 2.

Magnetic Resonance Imaging to Identify Glioblastoma Molecular Phenotypes.Chakraborty S, Priamo F, Boockvar JA.Neurosurgery. 2016 Feb;78(2):N20-1. doi: 10.1227/01.neu.0000479895.10242.9d. 

Multiportal Combined Transorbital and Transnasal Endoscopic Resection of Fibrous Dysplasia. Tham T, Costantino PD, Bruni M, Langer D, Boockvar J, Singh P [published online Oct 25 2015]. J Neurol Surg Rep. 2015. doi: 10.1055/s-0035-1566126

Repurposing mebendazole for the treatment of medulloblastoma. Bodhinayake I, Symons M, Boockvar JA. Neurosurgery. 2015 Feb;76(2):N15-6.doi:10.1227/01.neu.0000460594.93803.cb.No

Toxin-secreting implantable therapeutic stem cells. Gamble AJ, Boockvar JA. Neurosurgery. 2015 Apr;76(4):N16-8.

Isolated cortical vein thrombosis: case series. Singh R, Cope WP, Zhou Z, De Witt ME, Boockvar JA, Tsiouris AJ. J Neurosurg. 2015 Aug;123(2):427-33. doi: 10.3171/2014.9.JNS141813. Epub 2015 Mar 20.PMID: 25794339

A New Tool in Defining Disease Progression in Glioblastoma. De Witt ME, Boockvar JA. Neurosurgery. 2015 Aug;77(2):N13-5. doi: 10.1227/01.neu.0000467293.33634.17. No abstract available

Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. Gürsel DB, Banu MA, Berry N, Marongiu R, Burkhardt JK, Kobylarz K, Kaplitt MG, Rafii S, Boockvar JA. J Neurooncol. 2015 Jan;121(1):19-29. doi: 10.1007/s11060-014-1602-3. Epub 2014 Oct 26.

Multifunctionalization of cetuximab with bioorthogonal chemistries and parallel EGFR profiling of cell-lines using imaging, FACS and immunoprecipitation approaches. Reschke ME, Uprety R, Bodhinayake I, Banu M, Boockvar JA, Sauve AA. Biochim Biophys Acta. 2014 Aug 1. pii: S1570-9639(14)00195-2. doi: 10.1016/j.bbapap.2014.07.017. [Epub ahead of print]

Novel hydrogel application in minimally invasive surgical approaches to spontaneous intracranial hypotension. Chai CM, Banu MA, Cobb W, Mehta N, Heier L, Boockvar JA. J Neurosurg. 2014 Aug 1:1-7. [Epub ahead of print]

Targeting a Heterogeneous Tumor: The Promise of the Interleukin-13 Receptor α2. Bodhinayake I, Ottenhausen M, Boockvar JA. Neurosurgery. 2014 Aug;75(2):N18-9. doi: 10.1227/01.neu.0000452316.07108.d2. No abstract available.

Prophylactic plastic surgery closure of neurosurgical scalp incisions reduces the incidence of wound complications in previously-operated patients treated with bevacizumab (Avastin®) and radiation. Golas AR, Boyko T, Schwartz TH, Stieg PE, Boockvar JA, Spector JA. J Neurooncol. 2014 May 29. [Epub ahead of print

Phase I/II study of resection and intraoperative cesium-131 radioisotope brachytherapy in patients with newly diagnosed brain metastases. Wernicke AG, Yondorf MZ, Peng L, Trichter S, Nedialkova L, Sabbas A, Kulidzhanov F, Parashar B, Nori D, Clifford Chao KS, Christos P, Kovanlikaya I, Pannullo S, Boockvar JA, Stieg PE, Schwartz TH.J Neurosurg. 2014 Aug;121(2):338-48. doi: 10.3171/2014.3.JNS131140. Epub 2014 May 2.

The only way out is in: a deeper understanding of anti-VEGF therapy escape mechanisms offers possibilities for more effective antiangiogenic treatment. Ottenhausen M, Bodhinayake I, Boockvar JA. Neurosurgery. 2013 Dec;73(6):N9. doi: 10.1227/NEU.0000000000000210. No abstract available. PMID: 24257344 [PubMed - in process]

Results and risk factors for recurrence following endoscopic endonasal transsphenoidal surgery for pituitary adenoma. Bodhinayake I, Ottenhausen M, Mooney MA, Kesavabhotla K, Christos P, Schwarz JT, Boockvar JA. Clin Neurol Neurosurg. 2014 Apr;119:75-9. doi: 10.1016/j.clineuro.2014.01.020. Epub 2014 Jan 27. PMID: 24635930 [PubMed - in process

VIGAS and Beyond: The Impact of HCMV-Infection and Its Treatment in Glioblastoma. Ottenhausen M, Bodhinayake I, Schaefer PM, Boockvar JA. Neurosurgery. 2014 Apr;74(4):N17-8. doi: 10.1227/01.neu.0000445337.42703.0b. No abstract available. PMID: 24642991 [PubMed - in process]

Expanding the borders: the evolution of neurosurgical approaches. Ottenhausen M, Bodhinayake I, Evins AI, Banu M, Boockvar JA, Bernardo A. Neurosurg Focus. 2014 Apr;36(4):E11. doi: 10.3171/2014.2.FOCUS13547. PMID: 24684324 [PubMed - in process]

Conservative management of cavernous sinus cavernous hemangioma in pregnancy. Haber JS, Kesavabhotla K, Ottenhausen M, Bodhinayake I, Dinkin MJ, Segal AZ, Lee YM, Boockvar JA.J Neurosurg. 2014 Apr 11. [Epub ahead of print] PMID:24724853 [PubMed - as supplied by publisher]

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, Gursel D, Boockvar JA, Fischbach C. Cancer Res. 2013 Oct 11. [Epub ahead of print] PubMed PMID: 24121485.

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Kast RE, Boockvar JA et al. Oncotarget. 2013 April; 4(4): 502–530. Published online 2013 April 13.

Industry progress report on neuro-oncology: Biotech update 2013.Ottenhausen M, Bodhinayake I, Banu M, Kesavabhotla K, Ray A, Boockvar JA. J Neurooncol. 2013 Aug 16. [Epub ahead of print] PubMed PMID: 23949146.

Trials and tribulations of cancer immunotherapy: the dendritic cell vaccine shows promise in a phase I glioblastoma multiforme trial. Gürsel DB, Schlaff CD, Boockvar JA. Neurosurgery. 2012 Dec;71(6):N19-21. doi: 10.1227/01.neu.0000423045.97311.f7. PubMed PMID: 23160396.

Zero-profile Anchored Spacer Reduces Rate of Dysphagia Compared to ACDF With Anterior Plating. Hofstetter CC, Kesavabhotla K, Boockvar JA. J Spinal Disord Tech. 2013 Feb 19. [Epub ahead of print] PubMed PMID: 23429316.

Industry progress report on neuro-oncology: a biotech update. Haber JS, Banu MA, Ray A, Kesavabhotla K, Boockvar JA. J Neurooncol. 2013 Feb 20. [Epub ahead of print] PubMed PMID: 23423513.

Endoscopic endonasal transphenoidal surgery using BrainLAB headband for navigation without rigid fixation. Duque, Sara G, Gorrepati, Ramana, Kesavabhotla, K, Boockvar, JA. Journal of Neurological Surgery – Part A February 16, 2012 Manuscript ID: CEN-2012-02-OA-0607

EGFR Targeted Inhibition Resistance: Compensatory Activation of ERBB Family Members in Glioblastoma Cancer Stem-Like Cells Promotes Proliferation. Gursel DB, Boockvar JA, Schlaff, CD. Neurosurgery. 2012 Oct; 71(4):N17-18. PMID:22989968 [PubMed - in process]

Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis. Stessin AM, Schwartz A, Judanin G, Pannullo SC, Boockvar JA, Schwartz TH, Stieg PE, Wernicke AG. J Neurosurg. 2012 Aug 17. [Epub ahead of print]PMID:22900840[PubMed - as supplied by publisher]

Getting a neural stem cell from a fibroblast. Berry N, Gursel DB, Boockvar JA. Neurosurgery. 2012 Aug;71(2):N26-8. No abstract available. PMID:22811206[PubMed - in process]

Resetting the stem cell clock: impact of the systemic milieu on oligodendrocyte precursor cell differentiation and remyelination. Banu MA, Alter R, Boockvar JA. Neurosurgery. 2012 Jun;70(6):N15-7. No abstract available.

Therapeutic stem cells encapsulated in a synthetic extracellular matrix selectively kill tumor cells, delay tumor growth, and increase survival in a mouse resection model of malignant glioma. Gursel DB, Berry N, Boockvar JA. Neurosurgery. 2012 Jun;70(6):N17-9. No abstract available. PMID:22596007[PubMed - in process]

FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells. Stessin AM, Gursel DB, Schwartz A, Parashar B, Kulidzhanov FG, Sabbas AM, Boockvar J, Nori D, Wernicke AG. Neurosci Lett. 2012 May 16;516(2):253-8. Epub 2012 Apr 7.PMID:22507238

Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: From bedside to bench. Burkhardt JK, Hofstetter CP, Santillan A, Shin BJ, Foley CP, Ballon DJ, Pierre Gobin Y, Boockvar JA. J Clin Neurosci. 2012 Nov;19(11):1568-72. doi: 10.1016/j.jocn.2012.03.012. Epub 2012 Sep 15. PubMed PMID: 22985932.

Phase I/II study of oral erlotinib for treatment of relapsed/refractory glioblastoma multiforme and anaplastic astrocytoma. Kesavabhotla K, Schlaff CD, Shin B, Mubita L, Kaplan R, Tsiouris AJ, Pannullo SC, Christos P, Lavi E, Scheff R, Boockvar JA. J Exp Ther Oncol. 2012;10(1):71-81.PMID:22946346[PubMed - in process]

Short-term clinico-radiographic response to super-selective intra-arterial cerebral infusion of Bevacizumab for the treatment of vestibular schwannomas in Neurofibromatosis type 2. Riina HA, Burkhardt JK, Santillan A, Bassani L, Patsalides A, Boockvar JA. Interv Neuroradiol. 2012 Jun;18(2):127-32. Epub 2012 Jun 4.PMID:22681725[PubMed - in process]

Metabolic Response of Glioblastoma to Superselective Intra-Arterial Cerebral Infusion of Bevacizumab: A Proton Magnetic Resonance Spectroscopic Imaging Study. Jeon JY, Kovanlikaya I, Boockvar JA, Mao X, Shin B, Burkhardt JK, Kesavabhotla K, Christos P, Riina H, Shungu DC, Tsiouris AJ. AJNR Am J Neuroradiol. 2012 May 10. [Epub ahead of print]PMID:22576886

Intra-arterial bevacizumab with blood brain barrier disruption in a glioblastoma xenograft model. Burkhardt JK, Santillan A, Hofstetter CP, Christos P, Berry N, Shin BJ, Foley CP, Gürsel DB, Ballon DJ, Gobin YP, Boockvar JA. J Exp Ther Oncol. 2012;10(1):31-7.PMID:22946342

Super-selective basilar artery infusion of bevacizumab and cetuximab for multiply recurrent pediatric ependymoma. Rajappa P, Krass J, Riina HA, Boockvar JA, Greenfield JP.  Interv Neuroradiol. 2011 Dec;17(4):459-65. Epub 2011 Dec 16. PubMed PMID: 22192550.

Superselective intra-arterial cerebral infusion of novel agents after blood-brain disruption for the treatment of recurrent glioblastoma multiforme: a technical case series. Shin BJ, Burkhardt JK, Riina HA, Boockvar JA. Neurosurg Clin N Am. 2012 Apr;23(2):323-9. Epub 2012 Feb 18. PubMed PMID: 22440875.

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. Hofstetter CP, Burkhardt JK, Shin BJ, Gürsel DB, Mubita L, Gorrepati R, Brennan C, Holland EC, Boockvar JA.  PLoS One. 2012;7(1):e30059. Epub 2012 Jan 11. PubMed PMID: 22253878; PubMed Central PMCID: PMC3256196.

The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network. Gürsel DB, Berry N, Boockvar JA. Neurosurgery. 2012 Feb;70(2):N19-21. PubMed PMID: 22251985.

Dissecting the Perivascular Stem-Cell Niche: Can We Take Tumor Recurrence Down a NOTCH? Banu MA, Shin BJ, Boockvar JA.  Neurosurgery. 2012 Apr;70(4):N18-9. PubMed PMID: 22426056.

Notch Inhibition via Micro-RNA Blocks Glioma Development. Berry N, Gursel DB, Boockvar JA.  Neurosurgery. 2012 Apr;70(4):N20-2. PubMed PMID: 22426058.

Intra-arterial delivery of bevacizumab after blood-brain barrier disruption for the treatment of recurrent glioblastoma: progression-free survival and overall survival. Burkhardt JK, Riina H, Shin BJ, Christos P, Kesavabhotla K, Hofstetter CP, Tsiouris AJ, Boockvar JA.  World Neurosurg. 2012 Jan;77(1):130-4. Epub 2011 Nov 21. PubMed PMID: 22405392.

Cost analysis of intra-arterial versus intra-venous delivery of bevacizumab for the treatment of recurrent glioblastoma multiforme. Burkhardt JK, Shin BJ, Schlaff CD, Riina H, Boockvar JA. J Exp Ther Oncol. 2011;9(3):183-6. PubMed PMID: 22070049.

Neural stem cells and glioma stem-like cells respond differently to chemotherapeutic drugs: selectivity at the cellular level. Burkhardt JK, Shin BJ, Boockvar JA. Neurosurgery. 2011 Jun;68(6):N21-2. PubMed PMID: 21778947.

Direct conversion of human fibroblasts to functional neurons in one step. Berry N, Gursel DB, Boockvar JA. Neurosurgery. 2011 Dec;69(6):N18-9. PubMed PMID: 22067346.

Endovascular embolization of cervical hemangiopericytoma with Onyx-18: case report and review of the literature. Santillan A, Zink W, Lavi E, Boockvar J, Gobin YP, Patsalides A. J Neurointerv Surg. 2011 Sep;3(3):304-7. Epub 2010 Dec 8. PubMed PMID: 21990849.

Intra-arterial chemotherapy for malignant gliomas: a critical analysis. Burkhardt JK, Riina HA, Shin BJ, Moliterno JA, Hofstetter CP, Boockvar JA. Interv Neuroradiol. 2011 Sep;17(3):286-95. Epub 2011 Oct 17. PubMed PMID: 22005689

Glioblastoma Multiforme Stem-Like Cells and Hypoxia: The Novel Role of HAF. Shin B, Burkhardt JK, Boockvar J. Neurosurgery. 2011 Oct;69(4):N21. PubMed PMID: 21900808.

Glioblastoma Stem-Like Cells-Biology and Therapeutic Implications. Gürsel DB, Shin BJ, Burkhardt JK, Kesavabhotla K, Schlaff CD, Boockvar JA. Cancers (Basel). 2011 Jun 10;3(2):2655-2666. PubMed PMID: 21796273; PubMed Central PMCID: PMC3142771.

Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas. Hofstetter CP, Shin BJ, Mubita L, Huang C, Anand VK, Boockvar JA, Schwartz TH. Neurosurg Focus. 2011 Apr;30(4):E10. PubMed PMID: 21456921.

Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction. Gürsel DB, Beyene RT, Hofstetter C, Greenfield JP, Souweidane MM, Kaplitt M, Arango-Lievano M, Howard B, Boockvar JA. J Neurooncol. 2011 Sep;104(2):509-22. Epub 2011 Feb 19. PubMed PMID: 21336775.)

Generation of neural stem cells: a team approach. Hofstetter C, Boockvar J. Neurosurgery. 2010 Dec;67(6):N22-3. PubMed PMID: 21107172.

Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Boockvar JA, Tsiouris AJ, Hofstetter CP, Kovanlikaya I, Fralin S, Kesavabhotla K, Seedial SM, Pannullo SC, Schwartz TH, Stieg P, Zimmerman RD, Knopman J, Scheff RJ, Christos P, Vallabhajosula S, Riina HA. Clinical article. J Neurosurg. 2011 Mar;114(3):624-32. Epub 2010 Oct 22. PubMed PMID: 20964595.

Interstitial infusion of erlotinib in the rodent brain. Luther N, Karampelas I, Souliopoulos EP, Edgar MA, Boockvar JA, Souweidane MM. J Exp Ther Oncol. 2009;8(2):79-84. PubMed PMID: 20192114.

EGFR signaling is differentially activated in patient-derived glioblastoma stem cells. Howard BM, Gursel DB, Bleau AM, Beyene RT, Holland EC, Boockvar JA. J Exp Ther Oncol. 2010;8(3):247-60. PubMed PMID: 20734923.

Neural stem cells: targeting glioma in 3-dimensions. Hofstetter CP, Boockvar JA. Neurosurgery. 2010 Jun;66(6):N15. PubMed PMID: 20495412.

Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors? Cohan JN, Moliterno JA, Mok CL, Lavi E, Boockvar JA. J Neurooncol. 2011 Jan;101(2):301-6. Epub 2010 Jun 3. PubMed PMID: 20521161.

High-viscosity polymethylmethacrylate cement for endoscopic anterior cranial base reconstruction. Moliterno JA, Mubita LL, Huang C, Boockvar JA. J Neurosurg. 2010 Nov;113(5):1100-5. Epub 2010 Mar 26. PubMed PMID: 20345225.

Balloon-assisted superselective intra-arterial cerebral infusion of bevacizumab for malignant brainstem glioma. A technical note. Riina HA, Knopman J, Greenfield JP, Fralin S, Gobin YP, Tsiouris AJ, Souweidane MM, Boockvar JA. Interv Neuroradiol. 2010 Mar;16(1):71-6. Epub 2010 Mar 25. PubMed PMID: 20377982.

Superselective intraarterial cerebral infusion of bevacizumab: a revival of interventional neuro-oncology for malignant glioma. Riina HA, Fraser JF, Fralin S, Knopman J, Scheff RJ, Boockvar JA. J Exp Ther Oncol. 2009;8(2):145-50. PubMed PMID: 20192120.

Feasibility and safety of GliaSite brachytherapy in treatment of CNS tumors following neurosurgical resection. Wernicke AG, Sherr DL, Schwartz TH, Pannullo SC, Stieg PE, Boockvar JA, Ivanidze J, Moliterno JA, Parashar B, Trichter S, Sabbas AM, Nori D. J Cancer Res Ther. 2010 Jan-Mar;6(1):65-74. PubMed PMID: 20479550.

Forcing tumor stem cells to an end. Hofstetter CP, Boockvar JA. Neurosurgery. 2010 Apr;66(4):N17-8. PubMed PMID: 20305479.

Stem cell based growth factory delivery to the injured spinal cord. Boockvar JA, Hofstetter CP. Neurosurgery, 2010 Feb;66(2): N16-7

Tubular microsurgery for lumbar discectomies and laminectomies in obese patients; operative results and outcome. Tomasino A, Parikh K, Steinberger J, Knopman J, Boockvar JA, Hartl R. Spine. (Phila Pa 1976). 2009 Aug 15;34(18): E664-72.

Superselective intraarterial cerebral infusion of bevacizumab: a revival of interventional neuro-oncology for malignant glioma. Riina HA, Fraser JF, Fralin S, Knopman J, Scheff RJ, Boockvar JA. J Exp Ther Oncol. 2009;8(2):145-50. PubMed PMID: 20192120.

Reduction of seizures by transplantation of embryonic GABAergic interneurons into Kv1.1 mutant mice. Hofstetter C, Boockvar J. Neurosurgery. 2009 Dec;65(6):N8-9. PubMed PMID: 19934957

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, García-Verdugo JM, Roy NS, Boockvar JA. J Neurooncol. 2010 May;97(3):323-37. Epub 2009 Oct 24. PubMed PMID: 19855928.

The role of dose escalation with intracavitary brachytherapy in the treatment of localized CNS malignancies: outcomes and toxicities of a prospective study. Wernicke AG, Sherr DL, Schwartz TH, Pannullo SC, Stieg PE, Boockvar JA, Moliterno JA, Ivanidze J, Trichter S, Sabbas AM, Parashar B, Nori D. Brachytherapy. 2010 Jan-Mar;9(1):91-9. Epub 2009 Oct 21. PubMed PMID: 19850535.

Stem cell populated implanted trachea. Beyene R, Howard BM, Boockvar JA. Neurosurgery. 2009 May;64(5):N12-3. PubMed PMID: 19404132

Transformation of a low-grade pineal parenchymal tumour to secondary pineoblastoma. Howard BM, Hofstetter C, Wagner PL, Muskin ET, Lavi E, Boockvar JA. Neuropathol Appl Neurobiol. 2009 Apr;35(2):214-7. PubMed PMID: 19284482

Novel Treatment of Glioblastoma Multiforme Tumor Stem Cells with Oncolytic Viruses. Beyene, R., Boockvar, JA. July 2009: 65:1 Neurosurgery

Combined supraciliary and endoscopic endonasal approach for resection of frontal sinus mucoceles: technical note. Knopman J, Sigounas D, Huang C, Kacker A, Schwartz TH, Boockvar JA. Minim Invasive Neurosurg. 2009 Jun;52(3):149-51. Epub 2009 Jul 31. PubMed PMID: 19650020.

Tumor stem cells: will understanding a new paradigm lead to improved therapies? Howard B, Boockvar JA. Brain Expert Rev. Neurotherapeutics 8(4), 159-160 (2008)

Operative Results and Learning Curve with Microscope-Assisted Tubular Microsurgery for one and two discectomies and laminectomy.  Parikh K, Tomasino A, Knopman J, Boockvar JA, Hartl R. Neurosurg Focus, 25, 2: 1-6 2008

Results and risk factors for recurrence following single-level tubular lumbar microdiscectomy. Moliterno JA, Knopman J, Parikh K, Cohan JN, Huang QD, Aaker GD, Grivoyannis AD, Patel AR, Härtl R, Boockvar JA. J Neurosurg Spine. 2010 Jun;12(6):680-6. PubMed PMID: 20515355.

Disease-specific induced pluripotent stem cells. Beyene R, Boockvar JA.  Neurosurgery.  2008; 63(6):12

Stem Cell migration in a novel model to study pediatric brain tumors. Greenfield JP, Boockvar JA. Neurosurgery. 2008 Aug;63(2): N9

Endoscopic Endonasal Transsphenoidal Surgery using a Skull Reference Array and Laser Surface Scanning. Greenfield JP, Howard BM, Huang C, Boockvar JA. Minimally Invasive Neurosurgery. 51: 244-246. 2008.

Magnetic Resonance Spectroscopy Traces Neural Progenitor Cells in Vivo. Howard B, Boockvar JA.  Neurosurgery. 2008 Apr: 62(4):N12

Pluripotential stem cells from mature somatic cells. Howard BM, Boockvar JA, Dunn IF, Friedlander RM. Neurosurgery. 2008 Feb; 62 (2): N6-7.

Long-term expansion of adult human brain subventricular zone precursors. Ayuso-Sacido A, Roy NS, Schwartz TH, Greenfield JP, Boockvar JA. Neurosurgery. 2008 Jan;62(1):223-9; discussion 229-31. doi: 10.1227/01.NEU.0000311081.50648.4C. PubMed PMID: 18300911

Use of human neural tissue for the generation of progenitors. Greenfield JP, Ayuso-Sacido A, Schwartz TH, Pannullo S, Souweidane M, Stieg PE, Boockvar JA. Neurosurgery. 2008 Jan;62(1):21-37; discussion 27-30. doi: 10.1227/01.NEU.0000311059.87873.46. Review. PubMed PMID: 18300889.

Assessing neural stem cell motility using an agarose gel based microfluidic device. Wong K, Ayuso-Sacido A, Anhow P, Boockvar JA and Wu M., Journal of Visualized Experiments, Vol 1, 2008

A new strategy for analysis of phenotypic marker antigens in murine and human brain tumor derived neurospheres, Bleau A, Howard, B, Taylor L, Gursel D, Tung L, Greenfield, J, Holland EC, Boockvar, JA. Neurosurg Focus, 24 1-9, March/April 2008

SPORTing Statistics: Slicing the Drive on Appropriate Treatment.  Fraser, J., Hartl, R., Boockvar, JA. Neurology Alert, vol 2, 9-12, 2007

Intervertebral Disc Transplantation:  Treatment in Motion.  Fraser, J., Hartl, R., Boockvar, JA. Neurology Alert, vol 4, 20-22, 2007

Cell enhancer or cell transformer? Ayuso, A., Greenfield JP., Graham, C., Boockvar, JA.  The duality of EGFR signaling and neural stem cell phenotype: Current Stem Cell Research and Therapy, 2: 231-238, 2006

Experimental traumatic brain injury modulates the survival, migratory and terminal phenotype of transplanted EGFR activated neural stem cells. Boockvar JA, Schouten J, Royo N, Millard M, Spangler Z, Castelbuono D, Snyder E, O’Rourke D, McIntosh T.  Neurosurgery 56: 163-71, 2005

Dural Cavernous angioma of the posterior sagittal sinus. Boockvar JA, Stiefel M, Malhotra N, Dolinskas C, Dwyer-Joyce C, LeRoux PD: case report.  Surgical Neurology 63: 178-181, 2005

Constitutive EGFR signaling confers a motile phenotype to neural stem cells.  Boockvar JA, Kapitonov D, Schouten J, Counelis GJ, Kapoor G, Bogler O, Snyder E, McIntosh T, O’Rourke DM. Molecular and Cellular Neuroscience 24, (4): 1116-1130, 2003

Neural stem cell biology may be well suited for improving brain tumor therapies. Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY. Cancer J 9(3):189-204, 2003

Transplanted neural stem cells survive, differentiate and improve neurologic motor function after experimental traumatic brain injury. Riess P, Zhang C, Saatman K, Laurer HL, Teng T, Bareyre FM, Raghupathi R, Lenzlinger P, Longhi L, Lifshitz J, Neugebauer E, Boockvar JA, Snyder E, McIntosh TK.  Neurosurgery 51 (4): 1-11, 2002

Congenital cervical spinal stenosis and sports-related cervical cord neurapraxia in children. Boockvar JA, Durham S, Sun P.  Spine 26 (24): 2709-2712, 2001

The development of the Spitz-Holter valve in Philadelphia.  Boockvar JA, Loudon W, Sutton LN. Journal of Neurosurgery 95: 145-147, 2001

Surgical management of cubital tunnel syndrome. Boockvar JA, Zager EL: In Thieme’s (ed):  Seminars in Neurosurgery, Vol. 12 (1): 57-63, 2001

Results and risk factors for anterior cervicothoracic junction surgery. Boockvar JA, Phillips MF, Telfeian AE, O’Rourke D, Marcotte PJ.  Journal of Neurosurgery Spine 94: 12-17, 2001

Long-term deep brain stimulation in a patient with essential Tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Boockvar JA, Telfeian AE, Baltuch GH, Skolnick B, Simuni T, Stern M, Schmidt L, Trojanowski JQ.:  Journal of Neurosurgery 93: 140-144, 2000

Efficacy of unilateral deep brain stimulation of the VIM nucleus of the thalamus in a patient with bipolar disorder associated with Klinefelter’s syndrome and essential tremor.  Telfeian AE, Boockvar JA, Simuni T, Jaggi J, Skolnick B, Baltuch GH:  Journal of Neurosurgery 93: 127-128, 2000

Symptomatic lateral ventricular ependymal cysts: Criteria for distinguishing these rare cysts from other symptomatic cysts of the ventricles. Boockvar JA, Shafa B, Forman M, O’Rourke D.:  Case Report.  Neurosurgery 46(5): 1229-1233, 2000

Neurosurgery at the University of Pennsylvania Medical Center.  Boockvar JA, Virella A, Kotapka M, Flamm ES, Grady MS.:  Neurosurgery 46 (5): 1223-1228, 2000

Post-traumatic meningioma: case report and historical perspective.  Boockvar JA, Kotzen RA, Swanson R, Milhorat TH. J Neurol Neurosurg Psych 66: 796-798, 1999

Subacute paraparesis induced by venous thrombosis of a spinal angiolipoma. Boockvar JA, Black K, Malik S, Stanek A, Tracey KJ.: Spine 22:2304-2308, 1997

Erratum to: Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study.

Chakraborty S, Filippi CG, Wong T, Ray A, Fralin S, Tsiouris AJ, Praminick B, Demopoulos A, McCrea HJ, Bodhinayake I, Ortiz R, Langer DJ, Boockvar JA.

J Neurooncol. 2016 Jul

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