Restless legs syndrome


Restless legs syndrome is a sleep disorder in which a person experiences unpleasant sensations in the legs, which are described as:

  • Creeping
  • Crawling
  • Tingling
  • Pulling
  • Painful

These sensations usually occur in the calf area, but may be felt anywhere from the thigh to the ankle. One or both legs may be affected. For some people, the sensations are also felt in the arms. People with RLS have an irresistible urge to move the affected limb when the sensations occur. Moving often relieves the limb discomfort.

Some patients, however, have no definite sensation, except for the need to move. Sleep problems are common with RLS because of the difficulty it causes in getting to sleep. Severe daytime fatigue can be a significant problem for patients.


The cause of RLS is still unknown. Some cases are believed to be inherited, and some cases have been associated with nerve damage in the legs due to diabetes, kidney problems, or alcoholism. Iron deficiency can hasten the onset of RLS.

As many as 10% of people in the U.S. may have RLS.


Sensations occur when the person with RLS lies down or sits for prolonged periods of time, causing:

  • The need to move the legs for temporary relief of symptoms by:
    • Stretching or bending.
    • Rubbing the legs.
    • Tossing or turning in bed.
    • Getting up and pacing.
  • A definite worsening of the discomfort when lying down, especially when trying to fall asleep at night, or during other forms of inactivity, including just sitting.
  • A tedency to experience the most discomfort late in the day and at night.


Your healthcare provider can diagnose RLS based on your signs and symptoms, a complete medical history, and a physical examination. In addition, tests, such as laboratory tests including a ferritin level or a sleep study, may be performed. Currently, there is not a definitive test to diagnose restless legs syndrome.


Specific treatment for restless legs syndrome will be determined by your health care provider based on:

  • Your age, overall health, and medical history
  • Extent of the disease
  • Your tolerance for specific medications, procedures, or therapies
  • Expectations for the course of the disease
  • Your opinion or preference

Treatment options for restless legs syndrome may include:

  • Implementing a good sleep habits program
  • Eliminating activities that worsen symptoms
  • Eliminating caffeine, alcohol, and tobacco intake, which may worsen symptoms
  • Regular, moderate exercise
  • Maintaining a well-balanced diet
  • Treating underlying chronic conditions

Medications, including:

  • Dopaminergic agents (drugs that increase dopamine), which are largely used to treat Parkinson disease.
  • Benzodiazepines, such as clonazepam and diazepam.
  • Opioids, such as codeine, propoxyphene, or oxycodone.
  • Anticonvulsants, such as gabapentin and pregabalin.

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