Living with hyperhidrosis can be difficult, and finding the right treatment for your specific case may take time. If antiperspirants aren’t helpful, your doctor may suggest that you try medication.
Anticholinergic medications are drugs that block neurotransmitters. Glycopyrrolate, which is also called Robinul®, and oxybutynin, known as Ditropan®, help reduce the production of sweat. While these drugs are effective for some patients, they haven't been well studied, even though they've been used for years. They may also cause unpleasant side effects such as dry mouth, blurry vision, bloated feeling, constipation, decreased milk production, dizziness, drowsiness, enlarged pupils, headache, loss of taste, nausea, nervousness, sleeplessness and weakness.
There are some other systemic agents (medicines that affect your entire body) that have been used for hyperhidrosis treatment, including:
- Amitriptyline, clonazepam and beta blockers — which are antidepressants — and anti-anxiety treatments that can help with the physical manifestations of anxiety that cause you to perspire.
- Calcium channel blockers which are typically used in the treatment of blood pressure, can be helpful to patients with hyperhidrosis.
- Indomethacin and clonidine are sometimes used for the treatment of cranio facial and generalized hyperhidrosis.