Primary sclerosing cholangitis
Primary sclerosing cholangitis is a long-term disease that impacts the bile ducts located inside and outside of the liver. This condition causes inflammation and scarring which causes the bile ducts to become blocked and bile to accumulate in the liver. Bile is a digestive fluid that is made in the liver, when it accumulates in the liver it gradually begins to damage the liver cells and cause cirrhosis (scarring of the liver). A liver transplant may be recommended for patients with primary sclerosing cholangitis.
This condition advances very slowly and patients may have it for years before they experience symptoms. When symptoms do occur, they mostly commonly include fatigue, an intense itching of the skin and a yellowing of the skin and eyes (jaundice).