Center for Pituitary and Neuroendocrine Disorders Lenox Hill

Center for Pituitary and Neuroendocrine Disorders Lenox Hill

(212) 434-3900

130 E. 77th Street, 3 Black Hall
New York, New York 10075

About us

The Center for Pituitary and Neuroendocrine Disorders at Lenox Hill Hospital/Manhattan Eye Ear and Throat Hospital, provides interdisciplinary care for the diagnosis, evaluation, and treatment of tumors and disorders of the pituitary and anterior skull base.

Our physicians work closely with endocrinologists, neurosurgeons, otolaryngologists, ophthalmologists, neurologists, neuroradiologists, radiation oncologists and neuro-oncologists to provide minimally invasive state-of-the-art care for our patients.

Lenox Hill Hospital/MEETH Center for Pituitary and Neuroendocrine Disorders provides comprehensive care to patients with pituitary disorders and other disorders of the anterior skull base. Our team of physicians has years of experience in otolarynogology, endocrinology, neurosurgery and neurology and are recognized experts in the care of pituitary and neuroendocrine disorders.

We are an international referral center for patients with prolactinomas, acromegaly, Cushing's disease, Rathke's cleft cysts, craniopharyngiomas and other pituitary tumors, as well as hypothalamic tumors and meningiomas.We are located in one of the leading hospital centers for neurological care in New York City, and we are part of the largest health system in New York state.

The Center for Pituitary and Neuroendocrine Disorders at Lenox Hill Hospital

The Center for Pituitary and Neuroendocrine Disorders at Lenox Hill Hospital offers diagnostic and treatment services for disorders of the pituitary gland and anterior skull base.

Clinical expertise

The Center for Pituitary and Neuroendocrine Disorders provides diagnostic services and treatment for pituitary disorders.

Our interdisciplinary team of neuroendocrinologists, neurosurgeons, otolaryngologists, neurologists, neuroradiologists, radiation oncologists, ophthalmologists, and neuro-oncologists, work collaboratively to create individualized care plans for all our patients. We meet weekly at our Pituitary/Neuroendocrine Conference to discuss and optimize each patient's treatment plan to achieve optimal patient outcomes.

Our areas of multidisciplinary expertise include:

Pituitary Tumors

  • Acromegaly
  • Cushing's disease
  • All pituitary tumors and adenomas
  • Non-secreting pituitary adenomas
  • Prolactinomas
  • Recurrent pituitary adenomas
  • Thyrotroph adenomas

Cushing’s Disease

  • Adrenal Cushing's
  • Ectopic Cushing's
  • Iatrogenic Cushing's
  • Pituitary Cushing's
  • Recurrent Cushing's

Skull Base Tumors

  • Squamous cell carcinoma
  • Craniopharyngiomas
  • Clival tumors
  • Chordoma
  • Chondrosarcoma
  • Germinomas
  • Meningiomas
  • Gliomas
  • Hypophysitis and other inflammatory disorders
  • Rathke's cleft cyst
  • Sellar masses and adenomas
  • CNS sarcoid

Hormonal disorders

  • Growth hormone deficiency
  • Hypoadrenalism
  • Hypogonadism
  • Hypothyroidism (central)
  • Diabetes insipidus
  • Syndrome of inappropriate antiduretic hormone secretion
  • Prolactin disorders
  • Amenorrhea-galactorrhea syndrome
  • Drug-induced hyperprolactinemia
  • Infertility male hypogonadism
  • Posterior pituitary dysfunction disease
  • Hypopituitarism

Physicians

John Andrew Boockvar, MD

  • Vice Chair, Department of Neurosurgery,
    Lenox Hill Hospital
  • Director, Brain Tumor and Pituitary/ Neuroendocrine Center,
    Lenox Hill Hospital & Manhattan Eye, Ear and Throat Hospital
  • Investigator, Laboratory for Brain Tumor Biology,
    The Feinstein Institute for Medical Research
  • Professor, Neurosurgery and Otolaryngology/Head and Neck Surgery,
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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David Langer, MD

  • Chair, Department of Neurosurgery,
    Lenox Hill Hospital
  • Director,
    Moyamoya Center
  • Professor, Neurosurgery and Radiology,
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Heustein Lu Sy, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Peter David Costantino, MD

  • Chairman of Otolaryngology - Head and Neck Surgery, Lenox Hill Hospital
  • Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Alexis Matthew Demopoulos, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Jed Michael Pollack, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Richard Braunstein, MD

  • Executive Director,
    Manhattan Eye, Ear & Throat Hospital
  • Vice President, Ophthalmology Services,
    Northwell Health
  • Professor, Ophthalmology,
    Hofstra Northwell School of Medicine
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Jamie Roberts Mitchell, MD

  • Attending Neuro-ophthalmologist,
    Manhattan Eye, Ear & Throat Hospital and Lenox Hill Hospital
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Leonid Poretsky, MD

  • Director of Medicine - Endocrinology/Metabolism, Lenox Hill Hospital
  • Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Caroline Korsten Messer, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Minisha Sood, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Deborah Rachelle Shatzkes, MD

  • Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Jane Ari Lee, MD

Bidyut Kumar Pramanik, MD

  • Chief - Neuroradiology of Radiology, Lenox Hill Hospital
  • Associate Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Rafael Alexander Ortiz, MD

  • Chief, Neuro-Endovascular Surgery and Interventional Neuroradiology,
    Lenox Hill Hospital
  • Associate Professor, Neurosurgery, Neurology and Radiology,
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Anuj Goenka, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Christopher G. Filippi, MD

  • Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Dennis Harry Kraus, MD

  • Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Todd Arthur Anderson, MD

  • Assistant Professor, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
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Clinical Professionals

Sherese Fralin, MSN, FNP

  • Research Nurse Practictioner, Department of Neurosurgery,
    Lenox Hill Hospital
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Tamika Wong, MPH

  • Clinical Research Manager, Department of Neurosurgery,
    Lenox Hill Hospital
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Ashley Ray MS, FNP-BC

  • Nurse Practitioner, Department of Neurosurgery,
    Lenox Hill Hospital
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Publications

 

Frameless Stereotactic Insertion of Viewsite Brain Access System with Microscope-Mounted Tracking Device for Resection of Deep Brain Lesions: Technical Report. 
White T, Chakraborty S, Lall R, Fanous AA, Boockvar J, Langer DJ. Cureus. 2017 Feb 4;9(2):e1012. doi: 10.7759/cureus.1012.

Frameless and Maskless Stereotactic Navigation with a Skull-Mounted Tracker: A Technical Report. 
Fanous AA, White TG, Hirsch MB, Chakraborty S, Costantino PD, Langer DJ, Boockvar JA. World Neurosurg. 2017 Mar 11. pii: S1878-8750(17)30319-4. doi: 10.1016/j.wneu.2017.03.007. [Epub ahead of print]

Multiportal Combined Transorbital and Transnasal Endoscopic Resection of Fibrous Dysplasia. 
Tham T, Costantino PD, Bruni M, Langer D, Boockvar J, Singh P [published online Oct 25 2015].
J Neurol Surg Rep. 2015. doi: 10.1055/s-0035-1566126

Results and risk factors for recurrence following endoscopic endonasal transsphenoidal surgery for pituitary adenoma.
Bodhinayake I, Ottenhausen M, Mooney MA, Kesavabhotla K, Christos P, Schwarz JT, Boockvar JA.
Clin Neurol Neurosurg. 2014 Apr;119:75-9. doi: 10.1016/j.clineuro.2014.01.020. Epub 2014 Jan 27.
PMID: 24635930

Endoscopic Endonasal Transphenoidal Surgery Using the BrainLAB Headband for Navigation Without Rigid Fixation.
Duque SG, Gorrepati R, Kesavabhotla K, Huang C, Boockvar JA.
J Neurol Surg A Cent Eur Neurosurg. 2014 Jul;75(4):267-9. doi: 10.1055/s-0032-1331383. Epub 2013 Mar 19.
PMID: 23512589

Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas.
Hofstetter CP, Shin BJ, Mubita L, Huang C, Anand VK, Boockvar JA, Schwartz TH.
Neurosurg Focus. 2011 Apr;30(4):E10. doi: 10.3171/2011.1.FOCUS10317.
PMID: 21456921

Combined supraciliary and endoscopic endonasal approach for resection of frontal sinus mucoceles: technical note.
Knopman J, Sigounas D, Huang C, Kacker A, Schwartz TH, Boockvar JA.
Minim Invasive Neurosurg. 2009 Jun;52(3):149-51. doi: 10.1055/s-0029-1231068. Epub 2009 Jul 31.
PMID: 19650020

Endoscopic endonasal transsphenoidal surgery using a skull reference array and laser surface scanning. Greenfield JP, Howard BM, Huang C, Boockvar JA.
Minim Invasive Neurosurg. 2008 Aug;51(4):244-6. doi: 10.1055/s-2008-1073131.
PMID:18683120

Research

Clinical trials

Our patients have access to clinical studies offering novel, state-of the art therapies developed by our own physicians, as well as those that are done in collaboration with other sites. Ongoing trials include the following:
 

Phase I Trial of Super-Selective Intra-Arterial Infusion of Cetuximab (ERBITUX) with or without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck 
PI: John Boockvar, MD

This is an open-label, non-randomized, two arm, Phase I research study of superselective intraarterial Cetuximab (Erbitux) with or without radiation therapy for treatment of recurrent unresectable squamous cell carcinoma of the head and neck (HNSCC). Cetuximab has recently emerged as a promising biological agent in the management of HNSCC. It is an epidermal growth factor receptor (EGFR) inhibitor which increases the radiosensitivity of tumors to radiotherapy (RT), and has been proven to be effective. A large body of evidence supports the theoretical attractiveness of intra-arterial chemotherapy, related to the first pass of the drug through the tumor bed and to the possibility of increasing the doses of the chemotherapeutic agent, thus minimizing systemic toxic side effects. Theoretically, a higher dose of Cetuximab saturating the tumor tissue’s EGFR receptor will increase its responsiveness with or without concurrent radiation therapy.

A multi-center, randomized, open-label, Phase IV study to investigate the management of pasireotide-induced hyperglycemia with incretin based therapy or insulin in adult patients with Cushing’s disease or acromegaly
PI: John Boockvar, MD
Co-PI: Caroline Messer, MD

 

Lenox Hill Neurosurgery

PNA Spotlight: Dr. John Boockvar and Dr. Peter Costantino

The PNA Spotlight focuses on two surgeons who work side-by-side at the New York Head and Neck Institute at Lenox Hill Hospital: Dr. John Boockvar and Dr. Peter Costantino.

Medical Mystery

Dr. John Boockvar helped discover and treat a man’s rare diagnosis of Cushing’s disease.

Our centers

The Feinstein Institute for Medical Research

The researchers at the world-renowned Feinstein Institute for Medical Research are continually making advances in medicine.

130 E. 77th Street , 3 Black Hall
New York, New York 10075
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