Crigler-Najjar syndrome


Crigler-Najjar syndrome is a very rare condition where a substance made by the liver (bilirubin) cannot be broken down. In these cases, the enzyme that typically converts bilirubin into a form that can be removed by the body is not working correctly. Bilirubin begins to build up in the body and can lead to jaundice (a yellowing of the skin and eyes), along with damage to the brain, muscles and nerves.

This is an inherited syndrome.


Symptoms of Crigler-Najjar syndrome typically include jaundice, confusion and changes in thinking.

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