Lenox Hill Hospital, Feinstein Institute Study New Treatments for Aggressive Brain Cancer

Lead investigators of clinical research study, John Boockvar, MD and Marc Symons, PhD.

Physicians from the department of neurosurgery at Lenox Hill Hospital and scientists from the Laboratory for Brain Tumor Biology and Therapy at the Feinstein Institute for Medical Research, are participating in a clinical research study to obtain genetic information about one of the most aggressive forms of brain cancer – glioblastoma multiforme (GBM).

The study entitled,“Tissue Donation for Modeling Efficacy and Toxicity of Novel Therapeutic Modalities for Brain Tumors,” is being performed in collaboration with Champions Oncology, Inc. Marc Symons, PhD, a Feinstein Institute professor and John Boockvar, MD, director, Lenox Hill’s Brain Tumor Center, are working together as lead investigators of the project. 

“The purpose of the study is to collect brain tumor tissue samples from patients undergoing GBM surgery,” said Dr. Boockvar. “As part of the research, these tissue samples will be implanted into mice in a manner that preserves the biological characteristics of a human’s GBM. The goal is to grow and expand these cell cultures in mice so that we can gather invaluable information as to the genomics of this aggressive form of brain cancer and how we can tailor new therapeutic approaches that match the specific genetic makeup of the tumor.”

“The type of collaboration between a clinician at the bedside, and a research scientist at the bench is imperative in order to make meaningful strides in the treatment of human cancers,” said Dr. Symons. 

In addition to obtaining tissue samples, a small blood sample will also be collected which will be used for future research. Lenox Hill’s Brain Tumor Center plans to enroll 50 patients per year, over the course of two years. Study participants will be contacted by a Brain Tumor Center research nurse post surgery to obtain follow-up information including response to treatments, and overall survival to correlate this information to the information gleaned from the animal experiments.

For more information about this research study, contact Tamika Wong, MPH at 212-434-8436.


About Lenox Hill Hospital
Lenox Hill Hospital, a member of Northwell Health, is a 652-bed, fully accredited, acute care hospital located on Manhattan’s Upper East Side with a national reputation for outstanding patient care and innovative medical and surgical treatments. US News & World Report has ranked the hospital among the nation’s top 50 in Cardiology and Heart Surgery and among the top 10 hospitals in the state of New York with a total of 11 “high performing” designations for its clinical performance in Cancer, Diabetes & Endocrinology, Ear, Nose & Throat, Gastroenterology & GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology & Neurosurgery, Orthopedics, Pulmonology and Urology. For more information, go to www.lenoxhillhospital.org

About The Feinstein Institute
The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the 3,500 researchers and staff of the Feinstein are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine – a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit www.FeinsteinInstitute.org

Michelle Pipia-Stiles
[email protected]

Lenox Hill Hospital

Lenox Hill Hospital is a 652-bed, acute care hospital located on Manhattan's Upper East Side. A staple in the community for more than 150 years, the hospital has earned a national reputation for outstanding patient care and innovative medical and surgical treatments. The mission of Lenox Hill Hospital is to deliver outstanding healthcare with compassion and respect, to promote wellness in its communities, and to advance the field of medicine through education and research