New York, NY – A month into training at a Navy boot camp in Chicago, Nicholas Raimondo, 24, from Long Island, started having sudden headaches. Since the severity of his headaches subsided over time, he continued to train and graduated last January.
However, Mr. Raimondo’s girlfriend urged him to seek medical attention because his headaches never completely went away. A Navy physician performed a magnetic resonance imaging (MRI) scan, which showed a very large brain tumor. A biopsy in Chicago revealed that it was a glioblastoma multiforme.
Mr. Raimondo was referred to John Boockvar, MD, director of the Brain Tumor Center at Lenox Hill Hospital in Manhattan. Dr. Boockvar, a world-renowned neurosurgeon, performed another brain operation to more completely remove his cancer and to have his tumor genetically characterized by whole genome sequencing in collaboration with Rockefeller University and the New York Genome Center. Dr. Boockvar, who has pioneered an experimental brain cancer treatment using intra-arterial drug delivery, is spearheading a Phase I/II clinical trial entitled, “Repeated Super-Selective Intra-arterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed Glioblastoma Multiforme.”
“The purpose of the study is to learn whether bevacizumab given repeatedly, once every three months, through the arteries instead of the veins, is safe and effective when combined with chemoradiation in newly diagnosed patients with glioblastoma,” said Dr. Boockvar, principal investigator. “Additionally, one of the goals of the clinical trial is to determine if this treatment will help improve quality of life and extend survival.”
Mr. Raimondo is enrolled in the intra-arterial cerebral infusion clinical trial and received his first dose on April 4th.
Rafael Ortiz, MD, Lenox Hill’s chief of neuro-endovascular surgery and David Langer, MD, the hospital’s chair of neurosurgery, performed the procedure doing an intra-arterial Xper-computed tomography angiogram (CTA), cerebral angiogram and intra-arterial infusion of the drug bevacizumab. A catheter was navigated from the femoral artery (artery that takes blood to the leg) to the arteries supplying blood to the tumor. Contrast dye was injected though the catheter while performing a rotational 3-D Xper CT to accurately map the arteries supplying the tumor. Bevacizumab was delivered directly to the tumor instead of by systemic therapy (intravenously), which the investigators believe will result in better drug penetration with fewer side effects.
For more information about this clinical trial, please call Tamika Wong, clinical trials manager at Lenox Hill Hospital Neurosurgery at 212-434-3900, option 3, or [email protected].
About Northwell Health
Northwell Health (formerly North Shore-LIJ Health System) is New York State’s largest health care provider and private employer. With 21 hospitals and nearly 450 outpatient practices, we serve more than 1.8 million people annually in the metro New York area and beyond. Our 61,000 employees work to change health care for the better. We’re making breakthroughs in medicine at the Feinstein Institute. We're training the next generation of medical professionals at the visionary Hofstra Northwell School of Medicine and the School of Graduate Nursing and Physician Assistant Studies. And we offer health insurance through CareConnect. For information on our services in more than 100 medical specialties, visit Northwell.edu.
About Lenox Hill Hospital
Lenox Hill Hospital, a member of Northwell Health, is a 652-bed, fully accredited, acute care hospital located on Manhattan’s Upper East Side with a national reputation for outstanding patient care and innovative medical and surgical treatments. US News & World Report has ranked the hospital among the nation’s top 50 in Cardiology and Heart Surgery and among the top 10 hospitals in the state of New York with a total of 11 “high performing” designations for its clinical performance in Cancer, Diabetes & Endocrinology, Ear, Nose & Throat, Gastroenterology & GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology & Neurosurgery, Orthopedics, Pulmonology and Urology. For more information, go to www.lenoxhillhospital.org.